Development of predictive equations for total body water using the deuterium-dilution method as the gold standard in a population of asymptomatic HIV-positive Zulu women in South Africa

  • Gurpreet Kindra University of KwaZulu-Natal
  • Anna Coutsoudis University of KwaZulu-Natal
  • Letitia Pillay University of KwaZulu-Natal
  • Andrew Kindness University of KwaZulu-Natal
Keywords: HIV, women, total body water (TBW), lean body mass (LBM), anthropometry, predictive equation, bio-electrical impedance analysis (BIA), Deuterium enrichment, FTIR

Abstract

Objectives: The study aimed to derive predictive equations for total body water determinations with bioelectrical impedance and anthropometric measurements in a population of asymptomatic human immunodeficiency virus (HIV) -positive Zulu women. Design: Cross-sectional data from within an ongoing prospective study that observed the effect of infant feeding mode on maternal and child health in a cohort of asymptomatic HIV-positive women were used for this objective. Setting: A community health centre in Durban. Subjects: Asymptomatic HIV-infected women who were not eligible for antiretroviral therapy. They were resident in the area and were of Zulu ethnicity. Outcome measures: Development of predictive equations for total body water. Results: Success was achieved in developing predictive equations for total body water using bioelectrical impedance analysis and anthropometric measurements that were specific to the HIV-positive female Zulu population. These equations were developed using the total body water that was obtained from deuterium-dilution method as a gold standard. Conclusion: These predictive equations are likely to be more valid for the HIV-positive female African populations of similar build than the current predictive equations that derive from the Western population.

Author Biographies

Gurpreet Kindra, University of KwaZulu-Natal
MBBS, MSc, PhD Research Clinician Department of Paediatrics and Child Health Nelson R Mandela School of Medicine University of KwaZulu-Natal
Anna Coutsoudis, University of KwaZulu-Natal
PhD Professor Department of Paediatrics and Child Health Nelson R Mandela School of Medicine University of KwaZulu-Natal
Letitia Pillay, University of KwaZulu-Natal
PhD Lecturer Department of Chemistry Westville Campus University of KwaZulu-Natal
Andrew Kindness, University of KwaZulu-Natal
PhD Deputy Dean Department of Chemistry Westville Campus University of KwaZulu-Natal
Published
2012-07-30
How to Cite
Kindra, G., Coutsoudis, A., Pillay, L., & Kindness, A. (2012). Development of predictive equations for total body water using the deuterium-dilution method as the gold standard in a population of asymptomatic HIV-positive Zulu women in South Africa. South African Journal of Clinical Nutrition, 25(4), 186-191. Retrieved from http://www.sajcn.co.za/index.php/SAJCN/article/view/618
Section
Original Research